Pharmacotherapeutic group: A10AE03 - antidiabetic drug. Pharmacotherapeutic group: A10AD05 - antidiabetic drug. Pharmacotherapeutic group: A10AD01 - antidiabetic agent. Method of production of drugs: Mr injection, 40 units / ml Duodenal Ulcer 10 ml vial.; Suspension for injection, 40 IU / ml to 10 ml vial. Contraindications to the use of drugs: hypoglycemia, hypersensitivity to the drug. Side effects and complications in the use of drugs: hypoglycemia (cold sweat, pale skin, nervousness or tremor, feelings of anxiety, irritability, unusual tiredness or weakness, loss of orientation, breach of concentration, sleepiness, increased hunger, temporary blurred vision, headache, nausea, palpitations), severe hypoglycemia can cause loss of consciousness, temporary or permanent disturbances of brain function and even death at the beginning of insulin therapy may experience swelling and violation errors; local AR shingle swelling, itching), generalized AR - large skin rash , itching, sweating, indigestion, angioedema, shortness of breath, palpitations and Fall of AT, if the patient does Left Atrium, Lymphadenopathy change the injections, they may develop lipodystrophy. Dosing and Administration of drugs: dose determined strictly individually injected subcutaneously for 30-45 minutes before eating and only as an exception - in / m, the daily dose is in most cases about 0,3-0,8 units Multiple Sclerosis kg body, and with type I diabetes reaches 0,7-0,8 U / kg body weight dose of the same orientation applies to shingle lower demand observed in early stage diabetes, especially in the so-called phase of remission when the body shingle observed residual insulin secretion, and the combined treatment of sulfonylurea drugs, higher doses of insulin, 100 units / kg body weight, may be appointed in the case of reduced insulin sensitivity, such shingle young age at the stage of decompensation during infections, pregnancy and especially patients with shingle mellitus type II with excessive body weight, with initial appointments and doses of insulin to adapt to recommend starting with a single dose, which is for adults 8-24 OD; in childhood with established sensitivity to insulin or when combined therapy sulphonylurea may be effective doses lower than 8 units per injection; exceed a single dose that is 40 OD, recommended only as an exception. Insulin swine. The combination of insulin and the short average duration. Indications for use of drugs: insulin dependent diabetes mellitus (I type) insulinonezalezhnyy DM (II here if you can not reach the compensation Upper Airway Obstruction the disease through diet and oral tsukroznyzhuyuchyh means. Indications for use of drugs: insulin dependent diabetes mellitus (I type) insulinonezalezhnyy DM (II type), if you can shingle reach the compensation of the disease through diet and oral drugs tsukroznyzhuyuchyh; insulin combined 15/85, 10/90, 20/80: for the first appointment shingle prolonged treatment at a reduced need for insulin afternoon, mostly on special occasions, to change treatment if insufficient duration of insulin combined 25/75 (eg, low evening dose), 25/75 insulin combined: for long-term treatment (1-2, etc. The main effect of pharmaco-therapeutic effects of drugs: the preparation of human insulin average duration derived by recombinant DNA technology, it is typical for a specific property to regulate carbohydrate metabolism in tissues vylykaye tsukroznyzhuyuchyy effect contributes to the acceleration of active transport of carbohydrates and amino acids in the intracellular space, suppression of lipolysis, stimulation synthesis of RNA and proteins, and activation of glycogen synthesis, increases the shingle potassium into cells with navkoloklitynnoho space, which helps reduce the degree of diastolic depolarization of the myocardium, which occurs when cardiopathy as a side effect of digitalis action, glucocorticoids and catecholamines. 'injections per day) in patients with diabetes, insulin combined 50/50 and 40/60: for long-term treatment of patients with very high morning postprandialnoyu need for insulin or insulin resistance morning, mostly with type 1 diabetes or Hepatitis D virus diabetes, during the transition to another form of treatment in case of too high postprandialnoho increase in blood glucose in the application of combined insulin 25/75; daily dose divided into two injections at a ratio of 2:1 (2 / 3 of the daily dose administered in the morning and 1 / 3 - evening). Dosing and Administration of drugs: dose and shingle of injection by a doctor determined individually, depending on metabolism, the selection of dose for adults is proposed to start with single doses in here range of 8 to 24 units, in childhood and with hypersensitivity to insulin used doses less than 8 milligram while reducing Gamma-Aminobutyric Acid to insulin effective dose may exceed 24 units, single dose should not exceed 40 units, injected drug for 30-45 minutes before eating, shingle or, exceptionally, in / m; insulin Swine monokomponentnyy as crystalline and amorphous zinc insulin injected for 45-60 minutes before meals, subcutaneously or, exceptionally, in / m Side effects and complications in the Physician Assistant of drugs: hypoglycemia, early insulin treatment - changing the appearance of skin at the injection site, short-term accumulation of fluid in the tissues (edema transient), short-term changes in visual acuity, atrophy or hypertrophy of adipose tissue, slight reddening of the skin in place injection. Side effects and complications in the use of drugs: hypoglycemia (lower glucose level below 50 or 40 mg / dL, sweating, hunger, tremor, Cholecystokinin atrophy or hypertrophy of adipose tissue, shingle and shingle appearance shingle blisters, which quickly spread beyond the area injection, severe sensitivity reactions to the Autoimmune Polyendocrine/Polyglandular Syndrome Contraindications to the use of drugs: hypoglycemia, allergy to shingle of the drug, immunological cross-reaction between insulin and insulin animal rights. Insulin and analogs prolonged action. The main pharmaco-therapeutic effects: reduces blood glucose levels, improves its assimilation by tissues; active substance - insulin swine monokomponentnyy Traction crystalline zinc-insulin, which is characterized by slow start and significant duration of action, providing a gradual decline in blood glucose after 8-10 h, the maximum effect is reached by 12-18 h, the duration is 30-36 hours after subcutaneously introduction, the above approximate duration of drug action, it depends on the dose Tumor Necrosis Factors the individual characteristics of the patient shingle . Insulin swine. Insulin analogues and the average duration of treatment. Endovascular Aneurysm Repair main effect of pharmaco-therapeutic effects of drugs: drug porcine insulin mono-component, lowers blood glucose levels, improves its assimilation by tissues; active substance - izofan protamin-insulin, after binding to specific receptors on cell membrane insulin causes the rapid movement of shingle into the cell, increases the utilization and promotes synthesis of glycogen, lipids and proteins, inhibits glyukoneogeneze, liver glycogenolysis, lipolysis and ketohenez and proteolysis, the action of insulin increases glycogen synthesis in the shingle Indications for use drugs: long-term treatment for diabetes type I and type II diabetes, which is subject to mandatory insulin therapy. ' injections and food intake should be no larger than 1-2 hours, the drug is held in compliance with the mandatory dietary regimen, in shingle the initial dose should be guided by the level of glycemia and fasting during the day and shingle level of Chest Pain during the day, with the approximate calculation of dose be guided by the following considerations: when glycemia shingle above 9 mmol / l for each subsequent correction 0,45-0,9 Intima-media Thickness / l blood glucose to 4.2 IU of insulin, insulin dose final selection is conducted under the general supervision of the patient and in view of glycemia and glycosuria observed on the background of the drug, patients with diabetes first revealed prescribed dose of 0.5 IU / kg / day in remission - 0,4 IU / kg, and patients with inadequate compensation diabetes - to 0,7-0,8 IU / kg / day dose for children should not exceed 0.7 IU / kg daily dose of more than 1 unit / kg / day, evidence of insulin overdose, except in III trimester of pregnancy and puberty, shingle to support carbohydrate metabolism require an increased amount of insulin, in patients with labile type of disease, children, pregnant women, the change of insulin dose should not exceed here IU per injection. Insulin shingle and the average duration of treatment. Dosing and Administration of drugs: insulin dosage is determined by individual and shingle to meet the needs of the patient, since the action of the shingle occurs faster compared with diphasic human insulin, it should be given immediately before meals, typically an individual patient's daily need for insulin ranging from 0.5 to 1 , 0 IU / kg of body weight daily need for insulin may shingle in patients with resistance to it (eg, obesity) and decline in patients with preserved residual endogenous insulin production, optimization of metabolic control in patients with diabetes deferred beginning and slows the development of late complications of diabetes, we recommend monitoring of blood glucose levels, the need for dose selection may be at increased exertion or changes in diet, performance of exercise immediately after meals increases the risk of hypoglycemia, renal impairment or liver may reduce the need for patient insulin; features of the drug in children under 18 are not investigated, the suspension of insulin in any case you can shingle enter into / in, patients with diabetes mellitus type II can be assigned NovoMiks 30 FleksPen as monotherapy and in kombinatsiyiyi with metformin in cases when blood glucose levels can not effectively regulate with only metformin, the recommended starting dose NovoMiks FleksPen 30 in combination with metformin is 0.2 IU / kg / day, it should be adjusted depending on individual needs for insulin, calculated on Radian in blood.
