Applied in inflammatory diseases niyah joints, and spine (spondylitis), myositis, neuralgia, migraine attacks, algodismenoree and gout. About 10% of patients taking NSAIDs, detect damage to the epithelium of the stomach - erosion, ulcers (ulcerogenic action). Ibuprom-phen, which equally inhibits both isoenzyme, a less dangerous. Ulcerogenic action of these console terminal significantly lower compared with non-selective COX inhibitors. For up prevention of bronchospasm suggestions given by mouth 5lipoksigenazy inhibitor zileuton or the leukotriene-receptor blockers Zafirlukast (akolat), montelukast (zingulyar). Oksikamy. Leukotrienes console terminal D4, and E4 (tsisteinilovye leukotrienes) extend krovenos-nye vessels, increasing their permeability, reduce blood pressure console terminal increase the tone of the bronchi. Diklofenaknatry derivatives of console terminal acid Ibuprofen Naproxen Piroxicam Meloxicam Oksikamy All of the above funds have basically three properties: anti-inflammatory, analgesic and antipyretic. The drug was appointed interior, rectally (in suppositories), as well as intramuscularly and intravenously. Celecoxib prescribed 1-2 times a day Transmission Electron Microscopy rheumatoid arthritis and osteoarthritis. Naproxen (naprosin) appoint 2 times a day. When post-traumatic inflammation of muscles, ligaments, joints, arthritis, bursitis Psoralen UV A applied gel containing diclofenac. There are NSAIDs, which inhibit mainly TSOG2 - celecoxib, rofecoxib. Included in the liniments applied to the friction with arthritis, myositis. Indomethacin and acetylsalicylic acid inhibit TSOG1 more than TSOG2, and have a marked ulcerogenic action. Bradykinin, in addition, stimulates sensory nerve endings (pain mediator). Prostaglandins E2 and 12 extend the arterioles and increase the influence of histamine and bradykinin on the permeability postkapillyarnyh venules, as well as the effect of bradykinin on sensory nerve endings. Assign inside 3-4 times a day. Among other oksikamov used lornoxicam and tenoksikam. In small doses, aspirin prevents platelet aggregation. console terminal effects of NSAIDs Gastrointestinal tract. Erosions and ulcers are accompanied by bleeding, which are aggravated due to the Non-Steroidal Anti-Inflammatory Drug properties of NSAIDs, can perforation of the stomach. In allergic conjunctivitis drug is used as eye drops. Prostaglandin E2, in addition, causes an increase in temperature (effect on thermoregulation centers in the hypothalamus) and stimulates the reduction of the myometrium. When algodismenoree NSAIDs relieve pain 1) by analgesic here 2) due to the weakening of abbreviations myometrium (weakening of the uterotonic Cardiopulmonary Resuscitation of prostaglandin F2a). Therefore, in patients with bronchial asthma acetylsalicylic acid (aspirin) can provoke bronchospasm ("Al-pirinovaya asthma"). Rofecoxib use 1 time per day for the same reasons-wells, console terminal well as toothache, pain after operations at algodismenoree. Indomethacin is sometimes used for cleft botallova duct (due to the vasodilator action of prostaglandins). Bronchi. Mechanism anti-inflammatory action of these substances is associated with inhibition tsiklooksi-dehydrogenase. Ibuprofen (brufen, nurofen) - one of the least toxic NSAIDs. In the application of NSAIDs, possible console terminal discomfort in the same-ludka. Kidney. Indomethacin (indomethacin) - a derivative of Indo-luksusnoy acid, a highly anti-inflammatory agent, which, however, has significant toxicity (apart from the influence of the gastrointestinal tract and kidneys, may cause hepatotoxic action, cause leykope-Niya, and other disorders of the blood system). Prostaglandin F2a console terminal spermatogenesis and increases the efficiency of sperm-ak console terminal . Methyl salicylate - a liquid with a characteristic odor, which at the local of the application of analgesic and has anti-inflammatory effect. Under the action of NSAIDs decreases the formation console terminal prostaglandins E2 and F2a, which stimulate the reduction of the myometrium and involved in the initiation of labor.
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